Key Takeaway: The current standard for hospital glucose management is point-of-care (POC) testing; however, blinded continuous glucose monitoring (CGM) has retrospectively shown POC testing to miss ~ 33% of hyperglycemic and up to 90% of hypoglycemic events. This RCT of 110 adults with type 2 diabetes compared real-time CGM (RT-CGM) using Dexcom G6 with POC in a non-ICU hospital setting. RT-CGM data were wirelessly transmitted from the bedside. Hospital telemetry monitored RT-CGM data and notified bedside nursing of glucose alerts and trends. Standardized protocols were used for interventions. The RT-CGM group demonstrated significantly lower mean glucose and percentage of time in hyperglycemia >250 mg/dL and higher median time in range 70–250 mg/dL compared with usual care. Percentage of time in hypoglycemia was very low. Researchers concluded RT-CGM can be used safely and successfully in a non-ICU hospital setting to improve glucose management.